For research use only. Not for therapeutic Use.
Isatoribine (Cat.No:I007315) is a synthetic nucleoside analog with immunomodulatory properties. It activates Toll-like receptor 7 (TLR7), leading to the production of interferons and other immune mediators. Isatoribine has been studied for its potential therapeutic applications in viral infections, cancer, and autoimmune diseases, demonstrating its ability to enhance immune responses and antiviral activity.
| Catalog Number | I007315 |
| CAS Number | 198832-38-1 |
| Synonyms | ANA245；Immusine；Isatoribine hydrate；Isatoribine monohydrate；D04619；7-thia-8-oxoguanosine.;5-amino-3-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)thiazolo[4,5-d]pyrimidine-2,7(3H,6H)-dione hydrate |
| Molecular Formula | C10H14N4O7S |
| Purity | ≥95% |
| Solubility | Soluble in DMSO, not in water |
| Storage | 0 - 4°C for short term , or -20°C for long term. |
| IUPAC Name | 5-amino-3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4H-[1,3]thiazolo[4,5-d]pyrimidine-2,7-dione;hydrate |
| InChI | InChI=1S/C10H12N4O6S.H2O/c11-9-12-6-5(7(18)13-9)21-10(19)14(6)8-4(17)3(16)2(1-15)20-8;/h2-4,8,15-17H,1H2,(H3,11,12,13,18);1H2/t2-,3-,4-,8-;/m1./s1 |
| InChIKey | BZWQQOVSUSJJJO-QAGDRQIHSA-N |
| SMILES | C(C1C(C(C(O1)N2C3=C(C(=O)N=C(N3)N)SC2=O)O)O)O.O |
| Reference | </br>1:Discovery of ANA975: an oral prodrug of the TLR-7 agonist isatoribine. Xiang AX, Webber SE, Kerr BM, Rueden EJ, Lennox JR, Haley GJ, Wang T, Ng JS, Herbert MR, Clark DL, Banh VN, Li W, Fletcher SP, Steffy KR, Bartkowski DM, Kirkovsky LI, Bauman LA, Averett DR.Nucleosides Nucleotides Nucleic Acids. 2007;26(6-7):635-40. PMID: 18066870 </br>2:Isatoribine, an agonist of TLR7, reduces plasma virus concentration in chronic hepatitis C infection. Horsmans Y, Berg T, Desager JP, Mueller T, Schott E, Fletcher SP, Steffy KR, Bauman LA, Kerr BM, Averett DR.Hepatology. 2005 Sep;42(3):724-31. PMID: 16116638 |
