Isavuconazonium sulfate

• CAT Number: I007373
• CAS Number: 946075-13-4
• Molecular Formula: C35H36F2N8O9S2
• Molecular Weight: 814.84
• Purity: ≥95%
• Synonyms: BAL8557; BAL-8557; BAL 8557; isavuconazole; Isavuconazonium sulfate; brand name: Cresemba.;1-((2R,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-4-(1-((methyl(3-(((methylglycyl)oxy)methyl)pyridin-2-yl)carbamoyl)oxy)ethyl
• Target: Fungal
• Solubility: Soluble in DMSO, not in water
• Storage: 0 - 4°C for short term , or -20°C for long term.
• IUPAC Name: [2-[1-[1-[(2R,3R)-3-[4-(4-cyanophenyl)-1,3-thiazol-2-yl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-1,2,4-triazol-4-ium-4-yl]ethoxycarbonyl-methylamino]pyridin-3-yl]methyl 2-(methylamino)acetate;hydrogen sulfate
• InChI: InChI=1S/C35H35F2N8O5S.H2O4S/c1-22(33-42-30(18-51-33)25-9-7-24(15-38)8-10-25)35(48,28-14-27(36)11-12-29(28)37)19-45-21-44(20-41-45)23(2)50-34(47)43(4)32-26(6-5-13-40-32)17-49-31(46)16-39-3;1-5(2,3)4/h5-14,18,20-23,39,48H,16-17,19H2,1-4H3;(H2,1,2,3,4)/q+1;/p-1/t22-,23?,35+;/m0./s1
• InChIKey: LWXUIUUOMSMZKJ-KLFWAVJMSA-M
• SMILES: C[C@@H](C1=NC(=CS1)C2=CC=C(C=C2)C#N)[C@](CN3C=[N+](C=N3)C(C)OC(=O)N(C)C4=C(C=CC=N4)COC(=O)CNC)(C5=C(C=CC(=C5)F)F)O.OS(=O)(=O)[O-]

Isavuconazonium sulfate（Cat No.:I007373）is a broad-spectrum antifungal prodrug used for the treatment of invasive fungal infections. It is converted in the body to its active form, isavuconazole, which inhibits fungal cell membrane synthesis by targeting lanosterol 14α-demethylase. This drug is effective against a range of fungi, including Aspergillus and Mucor species, and is indicated for the treatment of invasive aspergillosis and mucormycosis in adults. Isavuconazonium sulfate offers a convenient intravenous or oral administration option with a favorable safety profile, providing a vital therapeutic option for immunocompromised patients.