Ischemin

• CAT Number: I012549
• CAS Number: 1357059-00-7
• Molecular Formula: C15H17N3O4S
• Molecular Weight: 335.38
• Purity: ≥95%
• Synonyms: (E)-5-(2-Amino-4-hydroxy-5-methyl-phenylazo)-2,4-dimethyl-benzenesulfonic acid; 5-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-2,4-dimethyl-benzenesulfonic acid; MS120
• IUPAC Name: 5-[(2Z)-2-(2-amino-5-methyl-4-oxocyclohexa-2,5-dien-1-ylidene)hydrazinyl]-2,4-dimethylbenzenesulfonic acid
• InChI: InChI=1S/C15H17N3O4S/c1-8-4-10(3)15(23(20,21)22)7-12(8)17-18-13-5-9(2)14(19)6-11(13)16/h4-7,17H,16H2,1-3H3,(H,20,21,22)/b18-13-
• InChIKey: WGEVKJVUKOELFY-AQTBWJFISA-N
• SMILES: CC1=CC(=C(C=C1NN=C2C=C(C(=O)C=C2N)C)S(=O)(=O)O)C

Ischemin(CAT: I012549) is a selective inhibitor of JMJD2 histone demethylases (KDM4 family), which are enzymes involved in the epigenetic regulation of gene expression through histone lysine demethylation. By inhibiting JMJD2 activity, Ischemin alters chromatin structure and gene transcription, impacting processes like cell proliferation, DNA repair, and apoptosis. This mechanism makes Ischemin a valuable tool in epigenetics and oncology research, particularly for studying cancer progression and identifying potential therapeutic targets. Additionally, its role in modulating gene expression provides insights into the regulation of cellular stress responses and potential treatments for ischemic injuries and neurodegenerative diseases.