Ischemin sodium

• CAT Number: I007375
• Molecular Formula: C15H16N3NaO4S
• Molecular Weight: 357.36
• Purity: ≥95%
• Synonyms: Ischemin sodium salt; J28; J-28; J 28.;5-[(1E)-2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-2,4-dimethylbenzenesulfonic acid sodium
• Target: Epigenetics
• IC50: Bromodomain
• SMILES: O=S(C1=CC(/N=N/C2=CC(C)=C(O)C=C2N)=C(C)C=C1C)([O-])=O.[Na+]

Ischemin is a potent CBP bromodomain inhibitor. Schemin alters post-translational modifications on p53 and histones, inhibits p53 interaction with CBP and transcriptional activity in cells, and prevents apoptosis in ischemic cardiomyocytes.

Reference

1: Borah JC, Mujtaba S, Karakikes I, Zeng L, Muller M, Patel J, Moshkina N,
Morohashi K, Zhang W, Gerona-Navarro G, Hajjar RJ, Zhou MM. A small molecule
binding to the coactivator CREB-binding protein blocks apoptosis in
cardiomyocytes. Chem Biol. 2011 Apr 22;18(4):531-41. doi:
10.1016/j.chembiol.2010.12.021. PubMed PMID: 21513889; PubMed Central PMCID:
PMC3103858.