Isepamicin Sulphate

• CAT Number: A000118
• CAS Number: 67814-76-0
• Molecular Formula: C22H45N5O16S
• Molecular Weight: 667.68
• Purity: ≥95%
• Synonyms: Isepamicine (Isepamycin, sch21420) Sulphate
• Target: Bacterial
• Storage: Store at -20°C
• IUPAC Name: (2S)-3-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-2-[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxypropanamide;sulfuric acid
• InChI: InChI=1S/C22H43N5O12.H2O4S/c1-22(35)6-36-20(15(33)18(22)26-2)39-17-8(27-19(34)9(28)4-23)3-7(25)16(14(17)32)38-21-13(31)12(30)11(29)10(5-24)37-21;1-5(2,3)4/h7-18,20-21,26,28-33,35H,3-6,23-25H2,1-2H3,(H,27,34);(H2,1,2,3,4)/t7-,8+,9-,10+,11+,12-,13+,14-,15+,16+,17-,18+,20+,21+,22-;/m0./s1
• InChIKey: DDXRHRXGIWOVDQ-MGAUJLSLSA-N
• SMILES: C[C@@]1(CO[C@@H]([C@@H]([C@H]1NC)O)O[C@H]2[C@@H](C[C@@H]([C@H]([C@@H]2O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)CN)O)O)O)N)NC(=O)[C@H](CN)O)O.OS(=O)(=O)O

Isepamicin Sulphate（Cat No.:A000118）is an aminoglycoside antibiotic used primarily to treat serious bacterial infections, particularly those caused by Gram-negative bacteria, including resistant strains like Pseudomonas aeruginosa. It functions by inhibiting protein synthesis within bacterial cells, leading to bacterial death. As a modified version of gentamicin, isepamicin has improved resistance to bacterial enzymes that typically inactivate aminoglycosides, enhancing its effectiveness against drug-resistant pathogens. It is often used in severe infections, such as complicated urinary tract infections and respiratory infections, though it requires careful monitoring due to potential nephrotoxicity and ototoxicity.