For research use only. Not for therapeutic Use.
ISIS 104838 Sodium (Cat No.: I040048) is an antisense oligonucleotide designed to selectively inhibit tumor necrosis factor-alpha (TNF-α) expression. It is widely used in inflammation and autoimmune disease research, particularly for conditions like rheumatoid arthritis and Crohn’s disease. By blocking TNF-α mRNA translation, it reduces inflammation and immune activation. The sodium salt form enhances solubility and stability for in vitro and in vivo applications. ISIS 104838 Sodium is a valuable tool in developing targeted therapies for inflammatory and immune-mediated disorders.
| Purity | ≥95% |
| Reference | [1]. Sewell KL, Geary RS, Baker BF, et al. Phase I trial of ISIS 104838, a 2′-methoxyethyl modified antisense oligonucleotide targeting tumor necrosis factor-alpha. J Pharmacol Exp Ther. 2002;303(3):1334-1343. |
