For research use only. Not for therapeutic Use.
ISOBICYPHAT(cas 51052-72-3) is a non-competitive GABA antagonist and a potent convulsant by causing epileptoform seizures.
Organophosphorous compound,synthetic
(IC<sub>50</sub>) for blocking the GABA-dependent [<sup>36</sup>Cl] uptake in rat brain synaptosomes: 0.2 nM.<br>
(IC<sub>50</sub>) for the inhibition of [<sup>3</sup>H]-dihydropicrotoxin binding with the rat brain membrane P2 fraction: 8.0 μM; (Ticku M.);<br>
(IC<sub>50</sub>) for the inhibition of [<sup>35</sup>S]-tert.butyl-thionebicyclophosphate binding with human brain membranes: 480 nM. (Casida J.E.);<br>
experiments with [<sup>3</sup>H]-labeled GABA-competitive ligands (muscimol, flunitrazepam) showed no influence of Isobicyphat up to 10 μM.
| Catalog Number | T000107 |
| CAS Number | 51052-72-3 |
| Synonyms | 1,3-Propanediol, 2-(hydroxymethyl)-2-isopropyl-, cyclic phosphate (1:1) |
| Molecular Formula | C7H13O4P |
| Purity | ≥95% |
| Solubility | In alcohol and water |
| Storage | Store at room temperature. |
| IUPAC Name | 4-propan-2-yl-2,6,7-trioxa-1$l^{5} |
| InChI | InChI=1S/C7H13O4P/c1-6(2)7-3-9-12(8,10-4-7)11-5-7/h6H,3-5H2,1-2H3 |
| InChIKey | CIEZMYRJRCLYNF-UHFFFAOYSA-N |
| SMILES | CC(C)C12COP(=O)(OC1)OC2 |
| Reference | – Bellet E. M., Casida J. E., Sciences (1973). 182:1135-1136<br /> |
