Isocitric acid

• CAT Number: I042504
• CAS Number: 320-77-4
• Molecular Formula: C6H8O7
• Molecular Weight: 192.12
• Purity: ≥95%
• Synonyms: 1-hydroxypropane-1,2,3-tricarboxylic acid
• InChI: InChI=1S/C6H8O7/c7-3(8)1-2(5(10)11)4(9)6(12)13/h2,4,9H,1H2,(H,7,8)(H,10,11)(H,12,13)
• InChIKey: ODBLHEXUDAPZAU-UHFFFAOYSA-N
• SMILES: C(C(C(C(=O)O)O)C(=O)O)C(=O)O

Isocitric acid is an endogenous metabolite present in Saliva and Cellular_Cytoplasm that can be used for the research of Alzheimer’s Disease, Lewy Body Dementia and Anoxia[1][2][3].
Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites[1].

Reference

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.
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[2]. Tsuruoka M, et al. Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72.
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[3]. Zupke C, et al. Intracellular flux analysis applied to the effect of dissolved oxygen on hybridomas. Appl Microbiol Biotechnol. 1995 Dec;44(1-2):27-36.
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