Isoliquiritigenin

• CAT Number: I005698
• CAS Number: 961-29-5
• Molecular Formula: C15H12O4
• Molecular Weight: 256.30
• Purity: ≥95%
• Synonyms: GU-17
• Target: Aldose reductase
• Solubility: DMSO 20 mg/ml; Water <0.1 mg/ml
• Storage: 3 years -20C powder
• IC50: 320 nM
• IUPAC Name: (E)-1-(2,4-dihydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
• InChI: InChI=1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+
• InChIKey: DXDRHHKMWQZJHT-FPYGCLRLSA-N
• SMILES: C1=CC(=CC=C1/C=C/C(=O)C2=C(C=C(C=C2)O)O)O

Isoliquiritigenin（Cat No.:I005698）is a natural chalcone flavonoid derived from licorice root (Glycyrrhiza uralensis), widely studied for its antioxidant, anti-inflammatory, and anticancer properties. It works by inhibiting various signaling pathways, including NF-κB and MAPK, which are involved in inflammation and tumor growth. Isoliquiritigenin has shown potential in reducing oxidative stress, protecting liver function, and inducing apoptosis in cancer cells, making it a candidate for therapeutic development. Additionally, its estrogenic effects offer potential benefits in managing menopausal symptoms, highlighting its versatility in pharmacological and nutraceutical research.

Reference

[1]. Aida K, et al. Isoliquiritigenin: a new aldose reductase inhibitor from glycyrrhizae radix. Planta Med. 1990 Jun;56(3):254-8.
[2]. Sato Y, et al. Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. Biol Pharm Bull. 2007 Jan;30(1):145-9. 


[3]. Zhang X, Natural antioxidant-isoliquiritigenin ameliorates contractile dysfunction of hypoxic cardiomyocytes via AMPK signaling pathway. Mediators Inflamm. 2013;2013:390890. 


[4]. Qiao H, et al. Pharmacokinetics, biodistribution and bioavailability of isoliquiritigenin after intravenous and oral administration. Pharm Biol. 2013 Oct 9. 


[5]. Chen X, et al. Isoliquiritigenin inhibits the growth of multiple myeloma via blocking IL-6 signaling. J Mol Med (Berl). 2012 Nov;90(11):1311-9.