For research use only. Not for therapeutic Use.
Isomaltitol（Cat No.:I011933）, also known as Palatinit or Isomalt, is a sugar alcohol commonly used as a sweetener in food products. It is derived from sucrose and has a similar taste profile to sugar but with a lower caloric content. In addition to its use as a sweetener, there is some evidence suggesting that Isomaltitol may have potential benefits in aiding mucus clearance in individuals with cystic fibrosis.
| Catalog Number | I011933 |
| CAS Number | 534-73-6 |
| Synonyms | Isomaltitol; Palatinit; Isomalt;(2S,3R,4R,5R)-6-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)hexane-1,2,3,4,5-pentaol |
| Molecular Formula | C12H24O11 |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | -20°C |
| IUPAC Name | (2S,3R,4R,5R)-6-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,4,5-pentol |
| InChI | InChI=1S/C12H24O11/c13-1-4(15)7(17)8(18)5(16)3-22-12-11(21)10(20)9(19)6(2-14)23-12/h4-21H,1-3H2/t4-,5+,6+,7+,8+,9+,10-,11+,12-/m0/s1 |
| InChIKey | SERLAGPUMNYUCK-YJOKQAJESA-N |
| SMILES | C(C1C(C(C(C(O1)OCC(C(C(C(CO)O)O)O)O)O)O)O)O |
| Reference | </br>1: Abe K, Kuroda A, Takeshita R. Engineering of Escherichia coli to facilitate efficient utilization of isomaltose and panose in industrial glucose feedstock. Appl Microbiol Biotechnol. 2017 Mar;101(5):2057-2066. doi: 10.1007/s00253-016-8037-z. Epub 2016 Dec 8. PubMed PMID: 27933453; PubMed Central PMCID: PMC5309279.</br>2: Schröder S, Kröger L, Mattes R, Thiem J. Transglycosylations employing recombinant α- and β-galactosidases and novel donor substrates. Carbohydr Res. 2015 Feb 11;403:157-66. doi: 10.1016/j.carres.2014.05.005. Epub 2014 May 20. PubMed PMID: 24909380.</br>3: Evaldsson C, Rydén I, Uppugunduri S. Isomaltitol exacerbates neutrophilia but reduces eosinophilia: new insights into the sephadex model of lung inflammation. Int Arch Allergy Immunol. 2011;154(4):286-94. doi: 10.1159/000321820. Epub 2010 Oct 20. PubMed PMID: 20962533.</br>4: Uppugunduri S, Gautam C. Effects of uridine, isomatitol and 4-thiouridine on in vitro cell adhesion and in vivo effects of 4-thiouridine in a lung inflammation model. Int Immunopharmacol. 2004 Sep;4(9):1241-8. PubMed PMID: 15251120.</br>5: Cataldi TR, Campa C, Casella IG, Bufo SA. Determination of maltitol, isomaltitol, and lactitol by high-pH anion-exchange chromatography with pulsed amperometric detection. J Agric Food Chem. 1999 Jan;47(1):157-63. PubMed PMID: 10563865.</br>6: Smits-Van Prooije AE, De Groot AP, Dreef-Van der Meulen HC, Sinkeldam EJ. Chronic toxicity and carcinogenicity study of isomalt in rats and mice. Food Chem Toxicol. 1990 Apr;28(4):243-51. PubMed PMID: 2358250.</br>7: Rosiers C, Verwaerde F, Dupas H, Bouquelet S. New approach to the metabolism of hydrogenated starch hydrolysate: hydrolysis by the maltase/glucoamylase complex of the rat intestinal mucosa. Ann Nutr Metab. 1985;29(2):76-82. PubMed PMID: 3922278.</br>8: Ziesenitz SC. Bioavailability of glucose from Palatinit. Z Ernahrungswiss. 1983 Sep;22(3):185-94. PubMed PMID: 6417920.</br>9: Siebert G, Grupp U, Heinkel K. Studies on isomaltitol. Nutr Metab. 1975;18 Suppl 1:191-6. PubMed PMID: 1165864.</br>10: Musch K, Siebert G, Schiweck H, Steinle G. [Nutritional physiology of isomaltitol in the rat]. Z Ernahrungswiss Suppl. 1973;15:3-16. German. PubMed PMID: 4518248.</br>11: Gehring F. [Formation of acids by cariogenically important streptococci from sugars and sugar alcohols with special reference to isomaltitol and isomaltulose]. Z Ernahrungswiss Suppl. 1973;15:16-27. German. PubMed PMID: 4518246.</br></br> |
