Isopropenylboronic Acid Pinacol Ester

• CAT Number: R018418
• CAS Number: 126726-62-3
• Molecular Formula: C9H17BO2
• Molecular Weight: 168.043
• Purity: ≥95%
• Synonyms: 4,4,5,5-Tetramethyl-2-(1-methylethenyl)-1,3,2-dioxaborolane; 2-Isopropenyl-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(isopropenyl)-1,3,2-dioxaborolane; 4,4,5,5-Tetramethyl-2-(prop-1-en-2-yl)-1,3,2-dioxaborolane
• Storage: -20°C
• IUPAC Name: 4,4,5,5-tetramethyl-2-prop-1-en-2-yl-1,3,2-dioxaborolane
• InChI: InChI=1S/C9H17BO2/c1-7(2)10-11-8(3,4)9(5,6)12-10/h1H2,2-6H3
• InChIKey: SVSUYEJKNSMKKW-UHFFFAOYSA-N
• SMILES: B1(OC(C(O1)(C)C)(C)C)C(=C)C

Isopropenylboronic Acid Pinacol Ester (CAS 126726-62-3) is the reagent used in preparation of various therapeutic kinase and enzymatic inhibitors. It was used as a comonomer in radical polymerization with a wide range of common vinyl monomers for elucidation of the monomer character and syntheses of conventionally inaccessible copolymers.

Reference

1.Jiang, Jian-kang, et al. "Evaluation of thieno [3, 2-b] pyrrole [3, 2-d] pyridazinones as activators of the tumor cell specific M2 isoform of pyruvate kinase." Bioorganic & medicinal chemistry letters 20.11 (2010): 3387-3393.
2.Makino, Hiroshi, Tsuyoshi Nishikawa, and Makoto Ouchi. "Elucidating Monomer Character of an Alkenyl Boronate through Radical Copolymerization Leads to Copolymer Synthesis beyond the Limitation of Copolymerizability by Side-Chain Replacement." ACS Macro Letters 9 (2020): 788-793.