For research use only. Not for therapeutic Use.
Isorosmanol（Cat No.:I018468） is an abietane-type diterpene derived from sage leaves. It possesses several beneficial properties, including antioxidant, neuroprotective, and neurotrophic effects. Isorosmanol exhibits inhibitory activity against acetylcholinesterase (AChE), an enzyme involved in the breakdown of the neurotransmitter acetylcholine. Additionally, it can inhibit melanin synthesis, making it potentially useful in the treatment of hyperpigmentation disorders.
| Catalog Number | I018468 |
| CAS Number | 93780-80-4 |
| Molecular Formula | C₂₀H₂₆O₅ |
| Purity | ≥95% |
| Target | Cholinesterase (ChE) |
| Storage | -20°C |
| IUPAC Name | (1R,8R,9R,10S)-3,4,9-trihydroxy-11,11-dimethyl-5-propan-2-yl-16-oxatetracyclo[6.6.2.01,10.02,7]hexadeca-2,4,6-trien-15-one |
| InChI | InChI=1S/C20H26O5/c1-9(2)10-8-11-12(14(22)13(10)21)20-7-5-6-19(3,4)17(20)15(23)16(11)25-18(20)24/h8-9,15-17,21-23H,5-7H2,1-4H3/t15-,16+,17-,20-/m0/s1 |
| InChIKey | UXVPWKDITRJELA-CLWJZODNSA-N |
| SMILES | CC(C)C1=C(C(=C2C(=C1)C3C(C4C2(CCCC4(C)C)C(=O)O3)O)O)O |
| Reference | [1]. Miura K, et al. Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method. J Agric Food Chem. 2002 Mar 27;50(7):1845-51.<br>[2]. Park SY, et al. Neuroprotective and neurotrophic effects of isorosmanol. Z Naturforsch C. 2009 May-Jun;64(5-6):395-8.<br>[3]. Sallam A, et al. Acetylcholine esterase inhibitors and melanin synthesis inhibitors from Salvia officinalis. Phytomedicine. 2016 Sep 15;23(10):1005-11. |
