Isosilybin B

• CAT Number: I018330
• CAS Number: 142796-22-3
• Molecular Formula: C₂₅H₂₂O₁₀
• Molecular Weight: 482.44
• Purity: ≥95%
• Target: Apoptosis

Isosilybin B (Cat.No:I018330), a flavonolignan isolated from silymarin, has anti-prostate cancer (PCA) activity via inhibiting proliferation and inducing G1 phase arrest and apoptosis. Isosilybin B causes androgen receptor (AR) degradation.

Reference

[1]. Deep G, et al. Isosilybin B and isosilybin A inhibit growth, induce G1 arrest and cause apoptosis in human prostatecancer LNCaP and 22Rv1 cells. Carcinogenesis. 2007 Jul;28(7):1533-42.[2]. Deep G, et al. Isosilybin B causes androgen receptor degradation in human prostate carcinoma cells via PI3K-Akt-Mdm2-mediated pathway. Oncogene. 2008 Jun 26;27(28):3986-98.