Isosteviol

• CAT Number: I002953
• CAS Number: 27975-19-5
• Molecular Formula: C20H30O3
• Molecular Weight: 318.45
• Purity: ≥95%
• Target: NF-κB
• Solubility: 10 mM in DMSO
• Storage: Room Temperature
• IUPAC Name: (1R,4S,5R,9S,10R,13S)-5,9,13-trimethyl-14-oxotetracyclo[11.2.1.01,10.04,9]hexadecane-5-carboxylic acid
• InChI: InChI=1S/C20H30O3/c1-17-9-5-14-18(2)7-4-8-19(3,16(22)23)13(18)6-10-20(14,12-17)11-15(17)21/h13-14H,4-12H2,1-3H3,(H,22,23)/t13-,14-,17-,18+,19+,20-/m0/s1
• InChIKey: KFVUFODCZDRVSS-XGBBNYNSSA-N
• SMILES: CC12CCC3C4(CCCC(C4CCC3(C1)CC2=O)(C)C(=O)O)C

Isosteviol（Cat No.:I002953）, also known as (-)-Isosteviol, is a derivative of steviol glycosides formed through acid-catalyzed hydrolysis. This compound exhibits a range of pharmacological effects, including inhibition of DNA polymerase and DNA topoisomerase. Isosteviol demonstrates antibacterial, anticancer, and antituberculous activities. It has been investigated for its potential therapeutic applications in various diseases. Its ability to inhibit key enzymes involved in DNA replication and repair, coupled with its antimicrobial and anticancer properties, makes isosteviol an intriguing candidate for further research and development in the field of drug discovery.

Reference

[1]. Wong KL, et al. Isosteviol acts on potassium channels to relax isolated aortic strips of Wistar rat. Life Sci. 2004 Mar 26;74(19):2379-87.

[2]. Wong KL, et al. Isosteviol as a potassium channel opener to lower intracellular calcium concentrations in cultured aortic smooth muscle cells. Planta Med. 2004 Feb;70(2):108-12.

[3]. Wong KL, et al. Antiproliferative effect of isosteviol on angiotensin-II-treated rat aortic smooth muscle cells. Pharmacology. 2006;76(4):163-9.