Isosulfan Blue

For research use only. Not for therapeutic Use.

  • CAT Number: M015871
  • CAS Number: 68238-36-8
  • Molecular Formula: C27H31N2NaO6S2
  • Molecular Weight: 566.66
  • Purity: ≥95%
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Isosulfan Blue(Cat No.:M015871) is a synthetic dye used primarily in medical diagnostics, particularly in lymphography and sentinel lymph node mapping in patients with breast cancer and other malignancies. This blue dye helps surgeons identify and map lymph nodes during procedures, facilitating the removal of nodes likely to contain metastases. Upon injection, Isosulfan Blue binds to plasma proteins and is selectively taken up by the lymphatic system, allowing for visual tracking of lymph flow. Its use assists in the accurate staging of cancer and helps in making decisions regarding the extent of surgery needed.


Catalog Number M015871
CAS Number 68238-36-8
Synonyms

PATENT BLUE VIOLET F & D VERSION;PATENT BLUE V (V F) (C.I. no 42045 );Ethanaminium, N-4-4-(diethylamino)phenyl(2,5-disulfophenyl)methylene-2,5-cyclohexadien-1-ylidene-N-ethyl-, inner salt, sodium salt;Lymphazurin;N-[4-[[4-(Diethylamino)phenyl](2-sulf

Molecular Formula C27H31N2NaO6S2
Purity ≥95%
Storage -20°C
IUPAC Name sodium;2-[[4-(diethylamino)phenyl]-(4-diethylazaniumylidenecyclohexa-2,5-dien-1-ylidene)methyl]benzene-1,4-disulfonate
InChI InChI=1S/C27H32N2O6S2.Na/c1-5-28(6-2)22-13-9-20(10-14-22)27(21-11-15-23(16-12-21)29(7-3)8-4)25-19-24(36(30,31)32)17-18-26(25)37(33,34)35;/h9-19H,5-8H2,1-4H3,(H-,30,31,32,33,34,35);/q;+1/p-1
InChIKey NLUFDZBOHMOBOE-UHFFFAOYSA-M
SMILES CCN(CC)C1=CC=C(C=C1)C(=C2C=CC(=[N+](CC)CC)C=C2)C3=C(C=CC(=C3)S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+]
Reference

1: Hassanein AH, Sacks JM, Cooney DS. Optimizing perioperative lymphatic-venous
anastomosis localization using transcutaneous vein illumination, isosulfan blue,
and indocyanine green lymphangiography. Microsurgery. 2017 Aug 31. doi:
10.1002/micr.30222. [Epub ahead of print] PubMed PMID: 28858393.
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2: Weixler B, Rickenbacher A, Raptis DA, Viehl CT, Guller U, Rueff J, Zettl A,
Zuber M. Sentinel Lymph Node Mapping with Isosulfan Blue or Indocyanine Green in
Colon Cancer Shows Comparable Results and Identifies Patients with Decreased
Survival: A Prospective Single-Center Trial. World J Surg. 2017
Sep;41(9):2378-2386. doi: 10.1007/s00268-017-4051-2. PubMed PMID: 28508233.
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3: Weber JJ, Wong JH. Periareolar or Peritumoral Injection of Isosulfan Blue and
the Effect on the Number of Sentinel Lymph Nodes Examined. Am Surg. 2017 Jan
1;83(1):98-102. PubMed PMID: 28234133.

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4: Ren L, Liu Z, Liang M, Wang L, Song X, Wang S. 10 % fluorescein sodium vs 1 %
isosulfan blue in breast sentinel lymph node biopsy. World J Surg Oncol. 2016 Nov
3;14(1):280. PubMed PMID: 27809854; PubMed Central PMCID: PMC5093998.
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5: &#304;lem-&#214;zdemir D, Yararbas U, Zengel B, Ertan G, Asikoglu M. Preparation of
(99m)Tc-isosulfan blue for lymph node localization in rats (99m)Tc-isosulfan blue
for lymph node localization. Appl Radiat Isot. 2016 Dec;118:338-342. doi:
10.1016/j.apradiso.2016.10.007. Epub 2016 Oct 11. PubMed PMID: 27756051.
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6: Ortiz D, Alvikas J, Riker AI. A Case of Severe Anaphylactic Reaction Secondary
to Isosulfan Blue Dye Injection. Ochsner J. 2015 Summer;15(2):183-6. PubMed PMID:
26130983; PubMed Central PMCID: PMC4482562.
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7: O&#700;Reilly EA, Prichard RS, Al Azawi D, Aucharaz N, Kelly G, Evoy D, Geraghty J,
Rothwell J, O&#700;Doherty A, Quinn C, Skehan SJ, McDermott EW. The Value of Isosulfan
Blue Dye in Addition to Isotope Scanning in the Identification of the Sentinel
Lymph Node in Breast Cancer Patients With a Positive Lymphoscintigraphy: A
Randomized Controlled Trial (ISRCTN98849733). Ann Surg. 2015 Aug;262(2):243-8.
doi: 10.1097/SLA.0000000000001213. PubMed PMID: 25822674.

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