ISR-IN-1

• CAT Number: I041710
• CAS Number: 1628478-15-8
• Molecular Formula: C22H22Cl2F2N2O4
• Molecular Weight: 487.32
• Purity: ≥95%
• Synonyms: 2-(4-chloro-3-fluorophenoxy)-N-[4-[[2-(4-chloro-3-fluorophenoxy)acetyl]amino]cyclohexyl]acetamide
• InChI: InChI=1S/C22H22Cl2F2N2O4/c23-17-7-5-15(9-19(17)25)31-11-21(29)27-13-1-2-14(4-3-13)28-22(30)12-32-16-6-8-18(24)20(26)10-16/h5-10,13-14H,1-4,11-12H2,(H,27,29)(H,28,30)
• InChIKey: BLLMXZJTGLCEBP-UHFFFAOYSA-N
• SMILES: C1CC(CCC1NC(=O)COC2=CC(=C(C=C2)Cl)F)NC(=O)COC3=CC(=C(C=C3)Cl)F

ISR-IN-1 (Compound 48) is an inhibitor of the integrated stress response (EC50: 0.6 nM)[1].

Reference

[1]. Hearn BR, et al. Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response. ChemMedChem. 2016 Apr 19;11(8):870-80.
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