ISR-IN-2

• CAT Number: I041709
• CAS Number: 1628478-12-5
• Molecular Formula: C22H22Cl4N2O4
• Molecular Weight: 520.23
• Purity: ≥95%
• Synonyms: 2-(3,4-dichlorophenoxy)-N-[4-[[2-(3,4-dichlorophenoxy)acetyl]amino]cyclohexyl]acetamide
• InChI: InChI=1S/C22H22Cl4N2O4/c23-17-7-5-15(9-19(17)25)31-11-21(29)27-13-1-2-14(4-3-13)28-22(30)12-32-16-6-8-18(24)20(26)10-16/h5-10,13-14H,1-4,11-12H2,(H,27,29)(H,28,30)
• InChIKey: JNLGSKLUABTOBY-UHFFFAOYSA-N
• SMILES: C1CC(CCC1NC(=O)COC2=CC(=C(C=C2)Cl)Cl)NC(=O)COC3=CC(=C(C=C3)Cl)Cl

ISR-IN-2 (Compound 47) is an inhibitor of the integrated stress response (EC50: 0.8 nM)[1].

Reference

[1]. Hearn BR, et al. Structure-Activity Studies of Bis-O-Arylglycolamides: Inhibitors of the Integrated Stress Response. ChemMedChem. 2016 Apr 19;11(8):870-80.
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