For research use only. Not for therapeutic Use.
ITH12575, a CGP37157 derivative, is a potent and selective mNCX blocker. ITH12575 reduces Ca2+ influx through CALHM1 at low micromolar concentrations[1][2].
| Catalog Number | I007391 |
| CAS Number | 1802013-08-6 |
| Synonyms | 7-chloro-5-(2-propan-2-ylphenyl)-1,5-dihydro-4,1-benzothiazepin-2-one |
| Molecular Formula | C18H18ClNOS |
| Purity | ≥95% |
| InChI | InChI=1S/C18H18ClNOS/c1-11(2)13-5-3-4-6-14(13)18-15-9-12(19)7-8-16(15)20-17(21)10-22-18/h3-9,11,18H,10H2,1-2H3,(H,20,21) |
| InChIKey | RDMUJSJZBYAAEF-UHFFFAOYSA-N |
| SMILES | CC(C)C1=CC=CC=C1C2C3=C(C=CC(=C3)Cl)NC(=O)CS2 |
| Reference | [1]. Francisco J Martínez-Sanz, et al. Benzothiazepine CGP37157 Analogues Exert Cytoprotection in Various in Vitro Models of Neurodegeneration. ACS Chem Neurosci. 2015 Sep 16;6(9):1626-36. [2]. Ana J Moreno-Ortega, et al. Benzothiazepine CGP37157 and its 2′-isopropyl analogue modulate Ca2+ entry through CALHM1. Neuropharmacology. 2015 Aug;95:503-10. |
