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84625-61-6-Itraconazole Itraconazole

Itraconazole

For research use only. Not for therapeutic Use.

  • CAT Number: A000258
  • CAS Number: 84625-61-6
  • Molecular Formula: C₃₅H₃₈Cl₂N₈O₄
  • Molecular Weight: 705.63
  • Purity: ≥95%
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Related Small Molecules: Triflusal     Benazepril Hydrochloride     N-[4-[2-(2,4-dimethylphenoxy)phenyl]-1,3-thiazol-2-yl]-1,4,5,6-tetrahydropyrimidin-2-amine    
Research Areas: Cancer Disease Research     Cancer Immunotherapy     Cancer Metabolism Metastasis     Cancer Targeted Therapy     Fungal Infection     Infection Disease Research    

Itraconazole（Cat No.:A000258）is an antifungal agent used to treat various fungal infections, including those caused by dermatophytes, yeasts, and molds. It works by inhibiting fungal cell membrane synthesis, disrupting cell wall integrity, and impairing the function of enzymes essential for fungal growth. Often prescribed for systemic infections such as blastomycosis, histoplasmosis, and aspergillosis, Itraconazole is available in oral and intravenous formulations. It demonstrates good tissue penetration and is commonly used in immunocompromised patients. Careful monitoring of liver function is necessary due to potential hepatotoxicity and drug interactions.


Catalog Number A000258
CAS Number 84625-61-6
Synonyms

84625-61-6; Oriconazole; Sporanox; Itraconazolum [Latin]; ITRAZOLE

Molecular Formula C₃₅H₃₈Cl₂N₈O₄
Purity ≥95%
Target Stem Cell/Wnt
Solubility >8.8mg/mL in DMSO
Storage -20°C
IUPAC Name 2-butan-2-yl-4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one
InChI InChI=1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3/t25?,31-,35-/m0/s1
InChIKey VHVPQPYKVGDNFY-ZPGVKDDISA-N
SMILES CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5CO[C@](O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl
Reference

1: Le T, Adenis A, Limper A, Harrison T. Itraconazole and antiretroviral therapy:
strategies for empirical dosing – Author/’s reply. Lancet Infect Dis. 2017
Nov;17(11):1123-1124. doi: 10.1016/S1473-3099(17)30582-0. PubMed PMID: 29115263.
<br>

2: Schwartz IS, Wasserman S. Itraconazole and antiretroviral therapy: strategies
for empirical dosing. Lancet Infect Dis. 2017 Nov;17(11):1122-1123. doi:
10.1016/S1473-3099(17)30568-6. PubMed PMID: 29115262.

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3: Chiu HY, Chang WL, Tsai TF, Tsai YW, Shiu MN. Risk of Psoriasis Following
Terbinafine or Itraconazole Treatment for Onychomycosis: A Population-Based
Case-Control Comparative Study. Drug Saf. 2017 Nov 6. doi:
10.1007/s40264-017-0614-2. [Epub ahead of print] PubMed PMID: 29110252.
<br>

4: Solanki N, Gupta SS, Serajuddin ATM. Rheological analysis of
itraconazole-polymer mixtures to determine optimal melt extrusion temperature for
development of amorphous solid dispersion. Eur J Pharm Sci. 2017 Oct
30;111:482-491. doi: 10.1016/j.ejps.2017.10.034. [Epub ahead of print] PubMed
PMID: 29080855.
<br>

5: Zhang L, Liu Z, Yang K, Kong C, Liu C, Chen H, Huang J, Qian F. Tumor
Progression of Non-Small Cell Lung Cancer Controlled by Albumin and Micellar
Nanoparticles of Itraconazole, a Multitarget Angiogenesis Inhibitor. Mol Pharm.
2017 Nov 7. doi: 10.1021/acs.molpharmaceut.7b00855. [Epub ahead of print] PubMed
PMID: 29068216.

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6: Mugheirbi NA, Marsac PJ, Taylor LS. Insights into Water-Induced Phase
Separation in Itraconazole-Hydroxypropylmethyl Cellulose Spin Coated and Spray
Dried Dispersions. Mol Pharm. 2017 Nov 8. doi: 10.1021/acs.molpharmaceut.7b00499.
[Epub ahead of print] PubMed PMID: 29053281.
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7: Puls C, Johnson A, Young K, Hare J, Rosenkrans K, Young L, Moriello K.
Efficacy of itraconazole oral solution using an alternating-week pulse therapy
regimen for treatment of cats with experimental Microsporum canis infection. J
Feline Med Surg. 2017 Oct 1:1098612X17735967. doi: 10.1177/1098612X17735967.
[Epub ahead of print] PubMed PMID: 29025320.
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8: Denardi LB, Keller JT, de Azevedo MI, Oliveira V, Piasentin FB, Severo CB,
Santurio JM, Alves SH. Comparison Between Etest and Broth Microdilution Methods
for Testing Itraconazole-Resistant Aspergillus fumigatus Susceptibility to
Antifungal Combinations. Mycopathologia. 2017 Oct 9. doi:
10.1007/s11046-017-0208-7. [Epub ahead of print] PubMed PMID: 28994001.

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9: Giovane RA, Manhas P, Gates K. Itraconazole or Amphotericin B for
Talaromycosis. N Engl J Med. 2017 Oct 5;377(14):1402. doi: 10.1056/NEJMc1709123.
PubMed PMID: 28980793.
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10: Le T, Thwaites G, Wolbers M. Itraconazole or Amphotericin B for
Talaromycosis. N Engl J Med. 2017 Oct 5;377(14):1403. doi: 10.1056/NEJMc1709123.
PubMed PMID: 28976858.

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