Itraconazole-d3

• CAT Number: R044026
• CAS Number: 1217512-35-0
• Molecular Formula: C₃₅H₃₅D₃Cl₂N₈O₄
• Molecular Weight: 708.65
• Purity: ≥95%
• Synonyms: (+/-)-4-[4-[4-[4-[[(2R,4S)-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methyl-d3-propyl)-3H-1,2,4-triazol-3-one; Itrizole-d3; Oriconazole-d3; R-51211-d3; Sporamelt-d3
• Storage: -20°C
• IUPAC Name: 2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one
• InChI: InChI=1S/C35H38Cl2N8O4/c1-3-25(2)45-34(46)44(24-40-45)29-7-5-27(6-8-29)41-14-16-42(17-15-41)28-9-11-30(12-10-28)47-19-31-20-48-35(49-31,21-43-23-38-22-39-43)32-13-4-26(36)18-33(32)37/h4-13,18,22-25,31H,3,14-17,19-21H2,1-2H3
• InChIKey: VHVPQPYKVGDNFY-UHFFFAOYSA-N
• SMILES: CCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl

Itraconazole-d3（Cat No.:R044026） is a deuterated variant of Itraconazole, where three hydrogen atoms are replaced with deuterium, enhancing its molecular stability. This modification is crucial for detailed pharmacokinetic and metabolic studies of Itraconazole, a widely used antifungal medication. Itraconazole-d3 aids in tracing the absorption, distribution, and elimination processes of the drug, providing essential data for optimizing therapeutic regimens. It is particularly valuable in the development of more effective formulations and in studying drug interactions.