Itraconazole metabolite Hydroxy Itraconazole

• CAT Number: I000475
• CAS Number: 112559-91-8
• Molecular Formula: C35H38Cl2N8O5
• Molecular Weight: 721.60
• Purity: ≥95%
• Synonyms: OH-ITZ;hydroxy-ITZ
• Target: Metabolic Enzyme/Protease
• Solubility: 10 mM in DMSO
• Storage: 2°C to 8°C
• IUPAC Name: 4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(3-hydroxybutan-2-yl)-1,2,4-triazol-3-one
• InChI: InChI=1S/C35H38Cl2N8O5/c1-24(25(2)46)45-34(47)44(23-40-45)29-6-4-27(5-7-29)41-13-15-42(16-14-41)28-8-10-30(11-9-28)48-18-31-19-49-35(50-31,20-43-22-38-21-39-43)32-12-3-26(36)17-33(32)37/h3-12,17,21-25,31,46H,13-16,18-20H2,1-2H3
• InChIKey: ISJVOEOJQLKSJU-UHFFFAOYSA-N
• SMILES: CC(C(C)O)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OCC5COC(O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl

Hydroxy Itraconazole（Cat No.:I000475）is a major metabolite of itraconazole, formed through the metabolism of the parent compound by hepatic enzymes, primarily CYP3A4. It exhibits potent antifungal activity similar to itraconazole, inhibiting fungal cell membrane synthesis by blocking ergosterol biosynthesis. Hydroxy itraconazole contributes significantly to the overall antifungal effects of itraconazole, enhancing its pharmacological profile. Due to its prolonged half-life and high plasma concentration, hydroxy itraconazole plays an essential role in treating systemic fungal infections. It is widely used in clinical practice for the treatment of various fungal infections, particularly in immunocompromised patients.