ITSA-1

• CAT Number: I002540
• CAS Number: 200626-61-5
• Molecular Formula: C₁₃H₇Cl₂N₃O
• Molecular Weight: 292.12
• Purity: ≥95%
• Synonyms: (1H-benzo[d][1,2,3]triazol-1-yl)(2,4-dichlorophenyl)methanone
• Target: Epigenetics
• Solubility: DMSO ≥ 32 mg/mL
• Storage: Store at -20°C
• IUPAC Name: benzotriazol-1-yl-(2,4-dichlorophenyl)methanone
• InChI: InChI=1S/C13H7Cl2N3O/c14-8-5-6-9(10(15)7-8)13(19)18-12-4-2-1-3-11(12)16-17-18/h1-7H
• InChIKey: UVNLAUGZMOPBPR-UHFFFAOYSA-N
• SMILES: C1=CC=C2C(=C1)N=NN2C(=O)C3=C(C=C(C=C3)Cl)Cl

ITSA-1（Cat No.:I002540）is a selective inhibitor of the protein kinase casein kinase 2 (CK2), which is involved in regulating various cellular processes, including cell proliferation, differentiation, and apoptosis. By inhibiting CK2 activity, ITSA-1 disrupts signaling pathways associated with cancer development and progression. Preclinical studies have shown that ITSA-1 can induce apoptosis in cancer cells and enhance the effectiveness of other therapies, making it a promising candidate for cancer treatment. Its specificity and potency position ITSA-1 as a valuable tool for investigating CK2’s role in tumor biology and therapeutic resistance.

Reference

[1]. Koeller KM et al. Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histoneand tubulin acetylation. Chem Biol. 2003 May;10(5):397-410.