Ivabradine metabolite N-Demethyl Ivabradine hydrochloride

• CAT Number: I000981
• CAS Number: 1246638-08-3
• Molecular Formula: C26H35ClN2O5
• Molecular Weight: 491.02
• Purity: ≥95%
• Target: Drug Metabolite
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: 3-[3-[[(7S)-3,4-dimethoxy-7-bicyclo[4.2.0]octa-1,3,5-trienyl]methylamino]propyl]-7,8-dimethoxy-2,5-dihydro-1H-3-benzazepin-4-one;hydrochloride
• InChI: InChI=1S/C26H34N2O5.ClH/c1-30-22-11-17-6-9-28(26(29)14-18(17)12-23(22)31-2)8-5-7-27-16-20-10-19-13-24(32-3)25(33-4)15-21(19)20;/h11-13,15,20,27H,5-10,14,16H2,1-4H3;1H/t20-;/m1./s1
• InChIKey: MIIIKWNQFDQJGS-VEIFNGETSA-N
• SMILES: COC1=C(C=C2CC(=O)N(CCC2=C1)CCCNC[C@H]3CC4=CC(=C(C=C34)OC)OC)OC.Cl

N-Demethyl Ivabradine Hydrochloride(CAT: I000981) is a primary metabolite of ivabradine, a selective inhibitor of the cardiac pacemaker current (I_f) in the sinoatrial node. This metabolite retains pharmacological activity, contributing to the heart rate-lowering effects observed with ivabradine treatment. By modulating I_f current, it reduces heart rate without affecting myocardial contractility or blood pressure, making it valuable in studying cardiac electrophysiology and conditions such as chronic stable angina and heart failure. N-Demethyl Ivabradine Hydrochloride is instrumental in pharmacokinetic and pharmacodynamic studies, providing insights into drug metabolism, active metabolites, and the therapeutic optimization of I_f inhibitors.