Ivacaftor benzenesulfonate

• CAT Number: I000506
• CAS Number: 1134822-09-5
• Molecular Formula: C30H34N2O6S
• Molecular Weight: 550.67
• Purity: ≥95%
• Synonyms: (Z)-N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carbimidic acid compound with benzenesulfonic acid (1:1)
• Target: Autophagy
• Solubility: DMSO：≥ 79 mg/mL
• Storage: Store at -20°C
• IC50: 25 nM (F508del-CFTR);100 nM (G551D-CFTR)
• IUPAC Name: benzenesulfonic acid;N-(2,4-ditert-butyl-5-hydroxyphenyl)-4-oxo-1H-quinoline-3-carboxamide
• InChI: InChI=1S/C24H28N2O3.C6H6O3S/c1-23(2,3)16-11-17(24(4,5)6)20(27)12-19(16)26-22(29)15-13-25-18-10-8-7-9-14(18)21(15)28;7-10(8,9)6-4-2-1-3-5-6/h7-13,27H,1-6H3,(H,25,28)(H,26,29);1-5H,(H,7,8,9)
• InChIKey: YLVYFBOFAFDIBR-UHFFFAOYSA-N
• SMILES: CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C.C1=CC=C(C=C1)S(=O)(=O)O

Ivacaftor benzenesulfonate（Cat No.:I000506）is the benzenesulfonate salt form of Ivacaftor, a drug used to treat cystic fibrosis (CF) in patients with specific genetic mutations in the CFTR (cystic fibrosis transmembrane conductance regulator) gene. Ivacaftor works by potentiating the function of the CFTR protein, improving chloride ion transport across cell membranes, thereby enhancing lung function and reducing CF symptoms. It is typically used for patients with the G551D mutation and other CFTR gating mutations. Ivacaftor benzenesulfonate provides improved solubility and stability, ensuring effective delivery and absorption in therapeutic use.