For research use only. Not for therapeutic Use.
Potent inhibitor of Wnt/<span class=/’symbol/’>β</span>-catenin signaling (IC<sub>50</sub> = 25 nM). Has minimal effect on Notch and Hedgehog signaling pathways. Induces differentiation of cardiomyocytes from human ESCs and iPSCs.
| Catalog Number | I011135 |
| CAS Number | 686772-17-8 |
| Synonyms | N-(6-Methyl-2-benzothiazolyl)-2-[(3,4,6,7-tetrahydro-3-(2-methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-2-yl)thio]-acetamide |
| Molecular Formula | C₂₃H₂₀N₄O₃S₃ |
| Purity | ≥95% |
| Target | Wnt |
| Solubility | Soluble to 10 mM in DMSO with sonication |
| Storage | Store at +4C |
| InChI | InChI=1S/C23H20N4O3S3/c1-13-7-8-14-18(11-13)33-22(24-14)26-19(28)12-32-23-25-15-9-10-31-20(15)21(29)27(23)16-5-3-4-6-17(16)30-2/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28) |
| InChIKey | RHUJMHOIQBDFQR-UHFFFAOYSA-N |
| SMILES | O=C(NC1=NC2=CC=C(C)C=C2S1)CSC3=NC(CCS4)=C4C(N3C5=CC=CC=C5OC)=O |
