For research use only. Not for therapeutic Use.
IWP-O1（Cat No.:I011934） is a porcn inhibitor with EC50 of 80 pM in a Wnt signaling reporter assay in cultured cells. It can effectively inhibit the phosphorylation of Dvl2/3 in Hela cells. Moreover, IWP-O1 has good metabolic stability.
| Catalog Number | I011934 |
| CAS Number | 2074607-48-8 |
| Synonyms | IWP-O1; IWPO1; IWP O1.;5-Phenyl-N-(5-phenylpyridin-2-yl)-4-(pyridin-4-yl)-1H-1,2,3-triazol-1-acetamide, |
| Molecular Formula | C26H20N6O |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Storage | 2-8°C(protect from light) |
| IUPAC Name | N-(5-phenylpyridin-2-yl)-2-(5-phenyl-4-pyridin-4-yltriazol-1-yl)acetamide |
| InChI | InChI=1S/C26H20N6O/c33-24(29-23-12-11-22(17-28-23)19-7-3-1-4-8-19)18-32-26(21-9-5-2-6-10-21)25(30-31-32)20-13-15-27-16-14-20/h1-17H,18H2,(H,28,29,33) |
| InChIKey | GYYDQHBKIHQHEB-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)C2=CN=C(C=C2)NC(=O)CN3C(=C(N=N3)C4=CC=NC=C4)C5=CC=CC=C5 |
| Reference | </br>1: You L, Zhang C, Yarravarapu N, Morlock L, Wang X, Zhang L, Williams NS, Lum L,</br> Chen C. Development of a triazole class of highly potent Porcn inhibitors. Bioorg</br> Med Chem Lett. 2016 Dec 15;26(24):5891-5895. doi: 10.1016/j.bmcl.2016.11.012.</br> Epub 2016 Nov 11. PubMed PMID: 27876319; PubMed Central PMCID: PMC5142825.</br> </br> |
