For research use only. Not for therapeutic Use.
<p style=/line-height:25px/>IWR-1(IWR-1-endo) is a novel small-molecule inhibitor of Wnt signaling by stabilizing the Axin destruction complex with an EC50 of 0.2 uM.<br>IC50 value: 0.2 uM (EC50) [1]<br>Target: Wnt signaling<br>During NSPC differentiation, MIF increased the activity of β-galactosidase that responds to Wnt/β-catenin signaling. Wnt1 and β-catenin proteins were also up-regulated with MIF stimulation. Moreover, the expression of DCX and Tuj 1 was inhibited significantly by IWR-1 [2]. FSH treatment increased CYP19A1, CCND2, CTNNB1, AXIN2 and FZD6 mRNAs and the stimulatory effect on CYP19A1 mRNA was reduced by IWR-1 [3].</p>
| Catalog Number | I000481 |
| CAS Number | 1127442-82-3 |
| Synonyms | 4-((3aR,4S,7R,7aS)-1,3-dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)-N-(quinolin-8-yl)benzamide |
| Molecular Formula | C25H19N3O3 |
| Purity | ≥95% |
| Target | Wnt/β-catenin |
| Solubility | DMSO: ≥ 46 mg/mL |
| Storage | 3 years -20C powder |
| IC50 | 0.2 uM (EC50) [1] |
| InChIKey | ZGSXEXBYLJIOGF-ALFLXDJESA-N |
| Reference | </br>1:Inhibition of collagen synthesis by IWR-1 in normal and keloid-derived skin fibroblasts. Zhou MW, Yin WT, Jiang RH, Lee JH, Kim CD, Lee JH, Zhu MJ, Yoon TJ.Life Sci. 2017 Mar 15;173:86-93. doi: 10.1016/j.lfs.2016.12.003. Epub 2016 Dec 7. PMID: 27939785 </br>2:IWR-1 inhibits epithelial-mesenchymal transition of colorectal cancer cells through suppressing Wnt/β-catenin signaling as well as survivin expression. Lee SC, Kim OH, Lee SK, Kim SJ.Oncotarget. 2015 Sep 29;6(29):27146-59. doi: 10.18632/oncotarget.4354. PMID: 26450645 Free PMC Article |
