IWR-1

• CAT Number: I000481
• CAS Number: 1127442-82-3
• Molecular Formula: C25H19N3O3
• Molecular Weight: 409.41
• Purity: ≥95%
• Synonyms: 4-((3aR,4S,7R,7aS)-1,3-dioxo-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindol-2(3H)-yl)-N-(quinolin-8-yl)benzamide
• Target: Organoid
• Solubility: DMSO: ≥ 46 mg/mL
• Storage: 3 years -20C powder
• IC50: 0.2 uM (EC50)
• IUPAC Name: 4-[(1S,2R,6S,7R)-3,5-dioxo-4-azatricyclo[5.2.1.02,6]dec-8-en-4-yl]-N-quinolin-8-ylbenzamide
• InChI: InChI=1S/C25H19N3O3/c29-23(27-19-5-1-3-14-4-2-12-26-22(14)19)15-8-10-18(11-9-15)28-24(30)20-16-6-7-17(13-16)21(20)25(28)31/h1-12,16-17,20-21H,13H2,(H,27,29)/t16-,17+,20-,21+
• InChIKey: ZGSXEXBYLJIOGF-ALFLXDJESA-N
• SMILES: C1[C@@H]2C=C[C@H]1[C@@H]3[C@H]2C(=O)N(C3=O)C4=CC=C(C=C4)C(=O)NC5=CC=CC6=C5N=CC=C6

IWR-1 (CAT: I000481) is a novel and selective Wnt signaling pathway inhibitor that functions by stabilizing the Axin destruction complex, leading to the degradation of β-catenin and suppression of Wnt target gene expression. It exhibits an EC₅₀ of 0.2 µM, demonstrating high potency in modulating Wnt activity. By promoting β-catenin degradation, IWR-1 disrupts aberrant Wnt signaling, which is frequently implicated in cancer and developmental disorders. This makes IWR-1 a valuable tool in oncology and stem cell research, particularly for studying colorectal cancer, fibrosis, and Wnt-driven tumor progression, as well as exploring regenerative medicine approaches.