IX 207-887

• CAT Number: I046307
• CAS Number: 98320-39-9
• Molecular Formula: C16H12O3S
• Molecular Weight: 284.33
• Purity: ≥95%
• Synonyms: (2Z)-2-(8-methoxy-6-thiatricyclo[8.4.0.03,7]tetradeca-1(14),3(7),4,8,10,12-hexaen-2-ylidene)acetic acid
• InChI: InChI=1S/C16H12O3S/c1-19-14-8-10-4-2-3-5-11(10)13(9-15(17)18)12-6-7-20-16(12)14/h2-9H,1H3,(H,17,18)/b13-9-
• InChIKey: XIKRQPKFOKKGGW-LCYFTJDESA-N
• SMILES: COC1=CC2=CC=CC=C2C(=CC(=O)O)C3=C1SC=C3

IX 207-887 is a novel antiarthritic agent which inhibits the release of interleukin-1 (IL-1).
IX 207-887 is a novel antiarthritic agent which inhibits the release of interleukin-1 (IL-1) from human monocytes and mouse peritoneal macrophages. In all test systems IX 207-887 significantly reduces both biologically active and immunoreactive IL-1 in culture media, whereas the levels of IL-1 in homogenates or lysates are either unaffected or only marginally reduced. IX 207-887 neither affects the adherence of human monocytes nor markedly inhibits IL-1 or IL-2-induced thymocyte proliferation. In the chondrocyte test no IL-1 antagonistic activity of IX 207-887 can be observed[1].

Reference

[1]. Schnyder J, et al. Inhibition of interleukin-1 release by IX 207-887. Agents Actions. 1990 Jun;30(3-4):350-62.
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