For research use only. Not for therapeutic Use.
J-147 (CAT: I000545) is a versatile neuroprotective compound that exhibits potent neurotrophic effects by stimulating the expression of brain-derived neurotrophic factor (BDNF). With an impressive EC50 range of 60-115 nM, J-147 offers broad-spectrum protection against neuronal degeneration. Its unique phenyl hydrazide structure contributes to its ability to enhance cellular resilience and promote neuron health.
| Catalog Number | I000545 |
| CAS Number | 1146963-51-0 |
| Synonyms | (Z)-N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N/’-(3-methoxybenzylidene)acetohydrazide |
| Molecular Formula | C18H17F3N2O2 |
| Purity | ≥95% |
| Target | Monoamine Oxidase |
| Solubility | 10 mM in DMSO |
| Storage | Store at +4C |
| IC50 | 60-115 nM in vitro assay [1] |
| InChI | InChI=1S/C18H17F3N2O2/c1-12-7-8-16(13(2)9-12)23(17(24)18(19,20)21)22-11-14-5-4-6-15(10-14)25-3/h4-11H,1-3H3/b22-11+ |
| InChIKey | HYMZAYGFKNNHDN-SSDVNMTOSA-N |
| SMILES | O=C(N(C1=CC=C(C)C=C1C)/N=C/C2=CC=CC(OC)=C2)C(F)(F)F |
| Reference | </br>1:SU-E-J-147: Dosimetric Consequences of Intrafraction Prostate Motion: Comparison Between Phantom Measurements and Three Different Calculation Methods. Schmitt D, Nill S, Roeder F, Herfarth K, Oelfke U.Med Phys. 2012 Jun;39(6Part8):3686. doi: 10.1118/1.4734984. PMID: 28518909 </br>2:J-147 a Novel Hydrazide Lead Compound to Treat Neurodegeneration: CeeTox<sup>™</sup> Safety and Genotoxicity Analysis. Lapchak PA, Bombien R, Rajput PS.J Neurol Neurophysiol. 2013 Aug;4(3). pii: 158. PMID: 25364619 Free PMC Article |
