For research use only. Not for therapeutic Use.
JAB-3068 (SHP2-IN-6) hydrochloride is a potent SHP2 inhibitor with an IC50 of 25.8 nM. JAB-3068 hydrochloride is extracted from patent WO2017211303A1, compound 7[1].
JAB-3068 hydrochloride inhibits the proliferation of KYSE-520 cells with an IC50 of 2.17 μM[1].
| Catalog Number | I045471 |
| CAS Number | 2169223-49-6 |
| Synonyms | 1-[4-[3-amino-5-[(4S)-4-amino-2-oxa-8-azaspiro[4.5]decan-8-yl]pyrazin-2-yl]sulfanyl-3,3-difluoro-2H-indol-1-yl]ethanone;hydrochloride |
| Molecular Formula | C22H27ClF2N6O2S |
| Purity | ≥95% |
| InChI | InChI=1S/C22H26F2N6O2S.ClH/c1-13(31)30-11-22(23,24)18-14(30)3-2-4-15(18)33-20-19(26)28-17(9-27-20)29-7-5-21(6-8-29)12-32-10-16(21)25;/h2-4,9,16H,5-8,10-12,25H2,1H3,(H2,26,28);1H/t16-;/m1./s1 |
| InChIKey | CVTYVQDHPFFBBF-PKLMIRHRSA-N |
| SMILES | CC(=O)N1CC(C2=C1C=CC=C2SC3=NC=C(N=C3N)N4CCC5(CC4)COCC5N)(F)F.Cl |
| Reference | [1]. Cunbo Ma, et al. Novel heterocyclic derivatives useful as shp2 inhibitors. WO2017211303A1. |
