JAG-1, scrambled TFA

• CAT Number: I044308
• Molecular Formula: C95H128F3N25O28S3
• Molecular Weight: 2221.37
• Purity: ≥95%

JAG-1, scrambled (scJag-1) TFA is a scrambled sequence of JAG-1 (Jagged-1 protein). JAG-1, scrambled TFA has a random sequence of the amino acids that are the same as the active fragment. JAG-1, scrambled TFA is usually used as a negative control[1].
In contrast to JAG-1, pretreatment of human pulmonary arterial smooth muscle cells (PASMC) with 50 μM scJag-1 TFA for 30 min has no effect on the transient and plateau components of store-operated Ca2+ entry (SOCE) in comparison to the cells treated with vehicle used to dissolve scJag-1[1].

Reference

[1]. Yamamura H, et al. Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca(2+) entry in human pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol. 2014 May 1;306(9):C871-8.
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