Jagged-1 (188-204) (TFA)

• CAT Number: I046139
• Molecular Formula: C95H128F3N25O28S3
• Molecular Weight: 2221.42
• Purity: ≥95%

Jagged-1 (188-204) TFA is a fragment of the Jagged-1 (JAG-1) protein with Notch agonist activity. JAG-1 is a Notch ligand highly expressed in cultured and primary multiple myeloma (MM) cells. JAG-1 induces maturation of monocyte-derived human dendritic cells[1][2][3].
Jagged-1 (188-204) TFA (40 μM, 72 h) mediates notch signaling activation to induce complete maturation of human keratinocyte by NF-kappaB and PPARgamma[2].
Jagged-1 (188-204) TFA (50 μM, 24 h) can enhance storage operation of Ca2+ entry in human pulmonary artery smooth muscle cells[3].

Reference

[1]. Jundt F, et al. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells. Blood. 2004 May 1;103(9):3511-5.
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[2]. Nickoloff BJ, et al. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ. 2002 Aug;9(8):842-55.
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[3]. Yamamura H, et al. Activation of Notch signaling by short-term treatment with Jagged-1 enhances store-operated Ca(2+) entry in human pulmonary arterial smooth muscle cells. Am J Physiol Cell Physiol. 2014 May 1;306(9):C871-8.
 [Content Brief]