JAK-IN-3

• CAT Number: I019400
• CAS Number: 1400876-94-9
• Molecular Formula: C18H20N4O3
• Molecular Weight: 340.38
• Purity: ≥95%
• Synonyms: 4-[[(2R,3R)-1,3-dihydroxybutan-2-yl]amino]-6-phenylpyrrolo[1,2-b]pyridazine-3-carboxamide
• InChI: InChI=1S/C18H20N4O3/c1-11(24)15(10-23)21-17-14(18(19)25)8-20-22-9-13(7-16(17)22)12-5-3-2-4-6-12/h2-9,11,15,21,23-24H,10H2,1H3,(H2,19,25)/t11-,15-/m1/s1
• InChIKey: PRWQQLFMBINSAW-IAQYHMDHSA-N
• SMILES: CC(C(CO)NC1=C(C=NN2C1=CC(=C2)C3=CC=CC=C3)C(=O)N)O

JAK-IN-3 (compound 22) is a potent JAK inhibitor, with IC50 values of 3 nM, 5 nM, 34 nM and 70 nM for JAK3, JAK1, TYK2 and JAK2, respectively[1].

Reference

[1]. Spergel SH, et al. Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis. ACS Med Chem Lett. 2019 Feb 13;10(3):306-311.
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