JAK1-IN-8

• CAT Number: I044406
• CAS Number: 1973485-18-5
• Molecular Formula: C22H23FN4O3S
• Molecular Weight: 442.51
• Purity: ≥95%
• Synonyms: N-[5-[4-[(1,1-dioxo-1,4-thiazinan-4-yl)methyl]-3-fluorophenyl]imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide
• InChI: InChI=1S/C22H23FN4O3S/c23-18-12-16(6-7-17(18)13-26-8-10-31(29,30)11-9-26)19-2-1-3-21-24-20(14-27(19)21)25-22(28)15-4-5-15/h1-3,6-7,12,14-15H,4-5,8-11,13H2,(H,25,28)
• InChIKey: QDYVZZJCRDVVQG-UHFFFAOYSA-N
• SMILES: C1CC1C(=O)NC2=CN3C(=N2)C=CC=C3C4=CC(=C(C=C4)CN5CCS(=O)(=O)CC5)F

JAK1-IN-8, a potent JAK1 inhibitor (IC50<500 nM), compound 28, extracted from patent WO2016119700A1[1].

Reference

[1]. Jin Li, et al. Composés d’imidazo[1,2-a]pyridin-2-ylamine substitués, compositions pharmaceutiques et leurs méthodes d’utilisation. Patent WO2016119700A1.