For research use only. Not for therapeutic Use.
JAK3 Inhibitor VI is a cell-permeable, potent, and reversible inhibitor of Janus kinase 3 (JAK3).
| Catalog Number | I029719 |
| CAS Number | 856436-16-3 |
| Synonyms | JAK3 Inhibitor VI; JAK-3 Inhibitor VI; JAK 3 Inhibitor VI |
| Molecular Formula | C19H17N3O4S |
| Purity | 98% |
| Target | Stem Cell/Wnt |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (Z)-3-((1H-Pyrrol-2-yl)methylene)-5-(pyridin-3-yl)indolin-2-one Mesylate |
| InChI | InChI=1S/C18H13N3O.CH4O3S/c22-18-16(10-14-4-2-8-20-14)15-9-12(5-6-17(15)21-18)13-3-1-7-19-11-13;1-5(2,3)4/h1-11,20H,(H,21,22);1H3,(H,2,3,4)/b16-10-; |
| InChIKey | ZUDPNBZMAJGYTE-HYMQDMCPSA-N |
| SMILES | O=C1NC2=C(C=C(C3=CC=CN=C3)C=C2)/C1=C/C4=CC=CN4.OS(=O)(C)=O |
| Reference | 1: Nishiya N, Sakamoto Y, Oku Y, Nonaka T, Uehara Y. JAK3 inhibitor VI is a mutant specific inhibitor for epidermal growth factor receptor with the gatekeeper mutation T790M. World J Biol Chem. 2015 Nov 26;6(4):409-18. doi: 10.4331/wjbc.v6.i4.409. PubMed PMID: 26629323; PubMed Central PMCID: PMC4657120. |
