JAK/HDAC-IN-1

• CAT Number: I019151
• CAS Number: 2284621-75-4
• Molecular Formula: C₁₉H₂₁Cl₂N₇O₂
• Molecular Weight: 450.32
• Purity: ≥95%

JAK/HDAC-IN-1(CAT: I019151) is a chemical compound designed to act as a dual inhibitor of Janus kinase (JAK) and histone deacetylase (HDAC) enzymes. JAK enzymes are involved in signal transduction pathways that regulate immune responses and hematopoiesis, while HDAC enzymes are responsible for the removal of acetyl groups from histone proteins, affecting gene expression. JAK/HDAC-IN-1 aims to inhibit both enzyme classes simultaneously, potentially modulating immune responses and gene expression patterns.

Reference

[1]. Liang X, et al. Discovery of Novel Janus Kinase (JAK) and Histone Deacetylase (HDAC) Dual Inhibitors for the Treatment of Hematological Malignancies. J Med Chem. 2019 Apr 25;62(8):3898-3923.