For research use only. Not for therapeutic Use.
Jaspamycin (Cat No.:I019392), also known as 7-CN-7-C-Ino, is a potent PKA activator that binds to its R site (PKAR) in Trypanosoma brucei, with EC50 and Kd values of 6.5, respectively nM and 8 nM. Jaspamycin (7-CN-7-C-Ino) does not bind purified human PKARIα.
| Catalog Number | I019392 |
| CAS Number | 22242-96-2 |
| Molecular Formula | C₁₂H₁₂N₄O₅ |
| Purity | ≥95% |
| Storage | Store at -20°C |
| IUPAC Name | 7-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-oxo-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile |
| InChI | InChI=1S/C12H12N4O5/c13-1-5-2-16(10-7(5)11(20)15-4-14-10)12-9(19)8(18)6(3-17)21-12/h2,4,6,8-9,12,17-19H,3H2,(H,14,15,20)/t6-,8-,9-,12-/m1/s1 |
| InChIKey | SKDKFLFSBDYEDO-WOUKDFQISA-N |
| SMILES | C1=C(C2=C(N1C3C(C(C(O3)CO)O)O)N=CNC2=O)C#N |
| Reference | [1]. Sabine Bachmaier, et al. Nucleoside analogue activators of cyclic AMP-independent protein kinase A of Trypanosoma. Nat Commun. 2019 Mar 29;10(1):1421. |
