JB002

• CAT Number: I041954
• CAS Number: 30408-07-2
• Molecular Formula: C18H15NO3
• Molecular Weight: 293.32
• Purity: ≥95%
• Synonyms: 3-(N-benzyl-C-methylcarbonimidoyl)-4-hydroxychromen-2-one
• InChI: InChI=1S/C18H15NO3/c1-12(19-11-13-7-3-2-4-8-13)16-17(20)14-9-5-6-10-15(14)22-18(16)21/h2-10,20H,11H2,1H3
• InChIKey: RLBBDEFOYCZVDK-UHFFFAOYSA-N
• SMILES: CC(=NCC1=CC=CC=C1)C2=C(C3=CC=CC=C3OC2=O)O

JB002 is a myosin II inhibitor, with an IC50 of ≤10 μM. JB002 can be used for the research of muscle spasticity, chronic musculoskeletal pain, and hypertrophic cardiomyopathy[1].
JB002 show promising selectivity between cardiac and skeletal myosin but have no detectible activity toward nonmuscle IIB[1].

Reference

[1]. Smith JD, et, al. Isoform selectivities of novel 4-hydroxycoumarin imines as inhibitors of myosin II. Eur J Med Chem. 2022 Dec 12;247:115008.
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