For research use only. Not for therapeutic Use.
JBJ-03-142-02 is a highly potent EGFR and ErbB2 inhibitor that inhibits wild type and mutated receptors.
| Catalog Number | I029749 |
| CAS Number | 2068806-31-3 |
| Synonyms | JBJ-03-142-02 |
| Molecular Formula | C25H22FN7O3 |
| Purity | 98% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (4-Fluorophenyl)methyl N-[2-[(1-methyl-1H-pyrazol-4-yl)amino]-4-pyrimidinyl]-N-[3-[(1-oxo-2-propen-1-yl)amino]phenyl]carbamate |
| InChI | InChI=1S/C25H22FN7O3/c1-3-23(34)29-19-5-4-6-21(13-19)33(25(35)36-16-17-7-9-18(26)10-8-17)22-11-12-27-24(31-22)30-20-14-28-32(2)15-20/h3-15H,1,16H2,2H3,(H,29,34)(H,27,30,31) |
| InChIKey | IFRXGTCPIGRGHP-UHFFFAOYSA-N |
| SMILES | O=C(OCC1=CC=C(F)C=C1)N(C2=NC(NC3=CN(C)N=C3)=NC=C2)C4=CC=CC(NC(C=C)=O)=C4 |
| Reference | 1: Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor Dr. Jaebong Jang, Dr. Jieun Son, Dr. Eunyoung Park, Dr. Takayuki Kosaka, Dr. Jamie A. Saxon, Dr. Dries J. H. De Clercq, Dr. Hwan Geun Choi, Dr. Junko Tanizaki, Dr. Michael J. Eck, Dr. Pasi A. Jänne, Dr. Nathanael S. Gray Angew Chem Int Ed Engl. Author manuscript; available in PMC 2018 Sep 3.Published in final edited form as: Angew Chem Int Ed Engl. 2018 Sep 3; 57(36): 11629 11633. Published online 2018 Aug 3. doi: 10.1002/anie.201805187 PMCID: PMC6118895 |
