JC-229

• CAT Number: I040822
• CAS Number: 3026716-22-0
• Molecular Formula: C20H14Cl4N2O3S
• Molecular Weight: 504.21
• Purity: ≥95%
• Synonyms: N-(3,4-dichlorophenyl)-3-[(3,4-dichlorophenyl)sulfamoyl]-4-methylbenzamide
• InChI: InChI=1S/C20H14Cl4N2O3S/c1-11-2-3-12(20(27)25-13-4-6-15(21)17(23)9-13)8-19(11)30(28,29)26-14-5-7-16(22)18(24)10-14/h2-10,26H,1H3,(H,25,27)
• InChIKey: HQDYAIBLPJRECW-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)Cl)Cl)S(=O)(=O)NC3=CC(=C(C=C3)Cl)Cl

JC-229(CAT: I040822) is a selective inhibitor of TbRPA1, a replication protein A1 in Trypanosoma brucei, the parasite responsible for Human African Trypanosomiasis (HAT), also known as sleeping sickness. By targeting TbRPA1, JC-229 disrupts DNA replication and repair processes essential for parasite survival, offering a promising approach for antiparasitic drug development. This compound is a valuable research tool for understanding the molecular mechanisms of T. brucei replication and for identifying therapeutic strategies against HAT. JC-229 demonstrates specificity toward the parasitic RPA1, making it suitable for studies focused on selective targeting and minimizing host toxicity in neglected tropical disease research.