For research use only. Not for therapeutic Use.
JC124 is a NLRP3 Inflammasome Inhibitor.
| Catalog Number | I029753 |
| CAS Number | 1638611-48-9 |
| Synonyms | JC124; JC-124; JC 124; |
| Molecular Formula | C17H19ClN2O4S |
| Purity | 98% |
| Target | NOD-like Receptor (NLR) |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 5-chloro-2-methoxy-N-(4-(N-methylsulfamoyl)phenethyl)benzamide |
| InChI | InChI=1S/C17H19ClN2O4S/c1-19-25(22,23)14-6-3-12(4-7-14)9-10-20-17(21)15-11-13(18)5-8-16(15)24-2/h3-8,11,19H,9-10H2,1-2H3,(H,20,21) |
| InChIKey | LXYPQRJNQPYTQW-UHFFFAOYSA-N |
| SMILES | O=C(NCCC1=CC=C(S(=O)(NC)=O)C=C1)C2=CC(Cl)=CC=C2OC |
| Reference | 1: Fulp J, He L, Toldo S, Jiang Y, Boice A, Guo C, Li X, Rolfe A, Sun D, Abbate A, Wang XY, Zhang S. Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization. J Med Chem. 2018 Jun 18. doi: 10.1021/acs.jmedchem.8b00733. [Epub ahead of print] PubMed PMID: 29877709. |
