JDTic

• CAT Number: I003327
• CAS Number: 361444-66-8
• Molecular Formula: C28H39N3O3
• Molecular Weight: 465.63
• Purity: ≥95%
• Synonyms: 7-hydroxy-N-(1-(4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl)-3-methylbutan-2-yl)-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
• Target: Neuronal Signaling
• Solubility: 10 mM in DMSO
• Storage: Store at -20°C
• IUPAC Name: (3R)-7-hydroxy-N-[(2S)-1-[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethylpiperidin-1-yl]-3-methylbutan-2-yl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide
• InChI: InChI=1S/C28H39N3O3/c1-18(2)26(30-27(34)25-13-20-8-9-24(33)12-21(20)15-29-25)17-31-11-10-28(4,19(3)16-31)22-6-5-7-23(32)14-22/h5-9,12,14,18-19,25-26,29,32-33H,10-11,13,15-17H2,1-4H3,(H,30,34)/t19-,25+,26+,28+/m0/s1
• InChIKey: ZLVXBBHTMQJRSX-VMGNSXQWSA-N
• SMILES: C[C@H]1CN(CC[C@@]1(C)C2=CC(=CC=C2)O)C[C@H](C(C)C)NC(=O)[C@H]3CC4=C(CN3)C=C(C=C4)O

JDTic(CAT: I003327) is a selective and potent antagonist of the kappa-opioid receptor (KOR), extensively studied in neuropharmacology and addiction research. By inhibiting KOR, JDTic has shown promise in modulating stress-related behaviors, mood disorders, and substance dependence. Its long-lasting activity and receptor specificity make it an essential tool for investigating the physiological and behavioral roles of the kappa-opioid system. JDTic is also valuable in exploring novel therapeutic strategies for treating depression, anxiety, and addiction. Its utility in preclinical studies provides researchers with insights into receptor-targeted interventions and the development of innovative central nervous system therapeutics.