For research use only. Not for therapeutic Use.
Jedi2 (CAT: I029769) is a specialized compound known as a Piezo1 channel activator. By interacting with Piezo1 channels, Jedi2 promotes the influx of calcium ions (Ca2+) into cells. This activation has been demonstrated in HEK293 cells that express Piezo1 channels, triggering specific responses. Importantly, Jedi2’s effect is selective for Piezo1 channels, as it induces responses in cells transfected with mouse Piezo1, but not in those expressing Piezo2 channels.
| Catalog Number | I029769 |
| CAS Number | 651005-90-2 |
| Synonyms | Jedi2 |
| Molecular Formula | C10H8O3S |
| Purity | 98% |
| Target | Piezo Channel |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 2-Methyl-5-(2-thienyl)-3-furancarboxylic acid |
| InChI | InChI=1S/C10H8O3S/c1-6-7(10(11)12)5-8(13-6)9-3-2-4-14-9/h2-5H,1H3,(H,11,12) |
| InChIKey | YXDCRSXNEOKXDE-UHFFFAOYSA-N |
| SMILES | O=C(C1=C(C)OC(C2=CC=CS2)=C1)O |
| Reference | Wang et al (2018) A lever-like transduction pathway for long-distance chemical- and mechano-gating of the mechanosensitive Piezo1 channel. Nat.Commun. 9 1300 PMID: 29610524 |
