For research use only. Not for therapeutic Use.
JFD01307SC（Cat No.:I015088）is a potent glutamine synthetase inhibitor known for its promising anti-tuberculosis activity, particularly against Mycobacterium tuberculosis. It acts by mimicking L-glutamate, effectively targeting enzymes crucial to glutamine biosynthesis, an essential pathway for bacterial growth and survival. With minimum inhibitory concentrations (MICs) between 8 and 16 µg/mL, JFD01307SC has shown potential in laboratory studies to inhibit bacterial proliferation. This unique mechanism positions JFD01307SC as a valuable compound in tuberculosis treatment research, offering a novel approach for tackling resistant strains of M. tuberculosis.
| Catalog Number | I015088 |
| CAS Number | 51070-56-5 |
| Molecular Formula | C₆H₁₁NO₄S |
| Purity | ≥95% |
| Target | Bacterial |
| IUPAC Name | 2-[(1,1-dioxothiolan-3-yl)amino]acetic acid |
| InChI | InChI=1S/C6H11NO4S/c8-6(9)3-7-5-1-2-12(10,11)4-5/h5,7H,1-4H2,(H,8,9) |
| InChIKey | NLJKAAYXSDTMSI-UHFFFAOYSA-N |
| SMILES | C1CS(=O)(=O)CC1NCC(=O)O |
| Reference | [1]. Gyanu Lamichhane, et al. Essential metabolites of Mycobacterium tuberculosis and their mimics. mBio. 2011 Feb 1;2(1):e00301-10. |
