JG-2016

• CAT Number: I040587
• CAS Number: 2887480-87-5
• Molecular Formula: C18H21ClN4O3
• Molecular Weight: 376.84
• Purity: ≥95%
• Synonyms: 7-chloro-8-ethyl-10-[2-(2-methylpropoxy)ethyl]benzo[g]pteridine-2,4-dione
• InChI: InChI=1S/C18H21ClN4O3/c1-4-11-7-14-13(8-12(11)19)20-15-16(21-18(25)22-17(15)24)23(14)5-6-26-9-10(2)3/h7-8,10H,4-6,9H2,1-3H3,(H,22,24,25)
• InChIKey: IOHJEWFKBRNJIO-UHFFFAOYSA-N
• SMILES: CCC1=CC2=C(C=C1Cl)N=C3C(=O)NC(=O)N=C3N2CCOCC(C)C

JG-2016 is a potent inhibitor of histone acetyltransferase 1 (HAT1), with an IC50 of 14.8 μM in the HAT1 acetylation assays[1].

Reference

[1]. Joshua James GRUBER, et al. Modulators of histone acetyltransferase 1 and methods of treatment thereof. Patent, WO2022272313A1.