For research use only. Not for therapeutic Use.
JG-98(Cat No.:I019052) is an allosteric inhibitor of heat shock protein 70 (Hsp70), which disrupts the Hsp70-Bag3 interaction by binding to a conserved site on Hsp70. It exhibits potent anti-cancer activities by affecting cancer cells and tumor-associated macrophages. JG-98 demonstrates antiproliferative activity across various cell lines, activates apoptotic mediators in cancer cells, and destabilizes FoxM1 to relieve downstream effector suppression. In xenograft models, JG-98 suppresses tumor growth. These findings suggest the potential of JG-98 as an anti-cancer therapeutic, targeting Hsp70, with broader effects on cancer cells and the tumor microenvironment.
| Catalog Number | I019052 |
| CAS Number | 1456551-16-8 |
| Molecular Formula | C₂₄H₂₁Cl₂N₃OS₃ |
| Purity | ≥95% |
| IUPAC Name | (2Z,5E)-2-[(3-benzyl-1,3-thiazol-3-ium-2-yl)methylidene]-5-(6-chloro-3-methyl-1,3-benzothiazol-2-ylidene)-3-ethyl-1,3-thiazolidin-4-one;chloride |
| InChI | InChI=1S/C24H21ClN3OS3.ClH/c1-3-28-21(14-20-27(11-12-30-20)15-16-7-5-4-6-8-16)32-22(23(28)29)24-26(2)18-10-9-17(25)13-19(18)31-24;/h4-14H,3,15H2,1-2H3;1H/q+1;/p-1/b24-22+; |
| InChIKey | AUPPGWXGMILTRB-HDPAMLMOSA-M |
| SMILES | CCN1/C(=C/C2=[N+](C=CS2)CC3=CC=CC=C3)/S/C(=C/4\N(C5=C(S4)C=C(C=C5)Cl)C)/C1=O.[Cl-] |
| Reference | [1]. Li X, et al. Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents. ACS Med Chem Lett. 2013 Nov 14;4(11).<br>[2]. Li X, et al. Validation of the Hsp70-Bag3 protein-protein interaction as a potential therapeutic target in cancer. Mol Cancer Ther. 2015 Mar;14(3):642-8.<br>[3]. Yaglom JA, et al. Cancer cell responses to Hsp70 inhibitor JG-98: Comparison with Hsp90 inhibitors and findingsynergistic drug combinations. Sci Rep. 2018 Feb 14;8(1):3010. |
