JH-X-119-01

• CAT Number: I029786
• CAS Number: 2227368-54-7
• Molecular Formula: C25H20N6O3
• Molecular Weight: 452.474
• Purity: 98%
• Synonyms: JH-X-119-01; JH-X119-01; JH-X 119-01; JH-X-11901; JH-X11901; JH-X 11901; JHX-11901; JHX11901; JHX 11901
• Target: IRAK
• Solubility: Soluble in DMSO
• Appearance: Solid powder
• Storage: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
• IUPAC Name: N-(4-(3-Acrylamidobenzamido)phenyl)-6-(1H-pyrazol-5-yl)picolinamide
• InChI: InChI=1S/C25H20N6O3/c1-2-23(32)27-19-6-3-5-16(15-19)24(33)28-17-9-11-18(12-10-17)29-25(34)22-8-4-7-20(30-22)21-13-14-26-31-21/h2-15H,1H2,(H,26,31)(H,27,32)(H,28,33)(H,29,34)
• InChIKey: WQVPGYMGERDXLH-UHFFFAOYSA-N
• SMILES: O=C(NC1=CC=C(NC(C2=CC=CC(NC(C=C)=O)=C2)=O)C=C1)C3=NC(C4=CC=NN4)=CC=C3

JH-X-119-01 (CAT: I029786) represents a novel and potent inhibitor of interleukin-1 receptor-associated kinases 1 (IRAK1). With its high selectivity, this compound has the potential to modulate signaling pathways that involve IRAK1, which plays a crucial role in immune responses and inflammation. By targeting IRAK1, JH-X-119-01 may offer therapeutic opportunities in conditions characterized by dysregulated immune activation and cytokine production.

Reference

Pan B, Gao J, Chen W, Liu C, Shang L, Xu M, Fu C, Zhu S, Niu M, Xu K. Selective inhibition of interleukin-1 receptor-associated kinase 1 ameliorates lipopolysaccharide-induced sepsis in mice. Int Immunopharmacol. 2020 Aug;85:106597. doi: 10.1016/j.intimp.2020.106597. Epub 2020 May 13. PMID: 32422509.