For research use only. Not for therapeutic Use.
JHDM-IN-1 (Compound 1) is a Jumonji C domain-containing HDMs (JHDM) inhibitor with IC50s of 3.4, 4.3, 5.9, 10 and 43 μM against JMJD2C, JMJD2A, JMJD2E, PHF8 and JMJD3, respectively[1].
JHDM-IN-1 (Compound 1) also inhibits FIH, PHD3, PHD1, PHD2 and LSD1 with IC50s of 22, 31, 54, 83 and 620 μM, respectively[1].
JHDM-IN-1 (0-100 μM) does not inhibit KYSE150 cell growth after treatment for 48 h[1].
| Catalog Number | I041140 |
| CAS Number | 1310809-17-6 |
| Synonyms | (E)-4-[hydroxy-[4-[[4-(naphthalen-1-ylcarbamoyloxymethyl)phenyl]methylamino]butyl]amino]-4-oxobut-2-enoic acid |
| Molecular Formula | C27H29N3O6 |
| Purity | ≥95% |
| InChI | InChI=1S/C27H29N3O6/c31-25(14-15-26(32)33)30(35)17-4-3-16-28-18-20-10-12-21(13-11-20)19-36-27(34)29-24-9-5-7-22-6-1-2-8-23(22)24/h1-2,5-15,28,35H,3-4,16-19H2,(H,29,34)(H,32,33)/b15-14+ |
| InChIKey | FOJNYQXAAPCEPX-CCEZHUSRSA-N |
| SMILES | C1=CC=C2C(=C1)C=CC=C2NC(=O)OCC3=CC=C(C=C3)CNCCCCN(C(=O)C=CC(=O)O)O |
| Reference | [1]. Luo X, et al. A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases. J Am Chem Soc. 2011 Jun 22;133(24):9451-6. |
