For research use only. Not for therapeutic Use.
JHU 37160 is a high affinity and highly potent activator of hM3Dq and hM4Di DREADDs. It displays approximately 25-fold higher affinity for hM4Di compared to DREADD agonist 21. It selectively displaces [3H]clozapine from DREADDs in vivo, but not from other clozapine binding sites. JHU 37160 inhibits locomotor activity in mice expressing hM3Dq and hM4Di in D1-expressing neurons, and increases hM3Dq-stimulated locomotion in rats expressing hM3Dq in TH-expressing neurons. It is a brain penetrant in mice, rats and non-human primates.
| Catalog Number | I029782 |
| CAS Number | 2369979-68-8 |
| Synonyms | JHU 37160; JHU37160; JHU-37160; |
| Molecular Formula | C19H20ClFN4 |
| Purity | 98% |
| Target | Neuronal Signaling |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | 8-chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5H-dibenzo[b,e][1,4]diazepine |
| InChI | InChI=1S/C19H20ClFN4/c1-2-24-8-10-25(11-9-24)19-14-4-3-5-15(21)18(14)22-16-7-6-13(20)12-17(16)23-19/h3-7,12,22H,2,8-11H2,1H3 |
| InChIKey | SWSCWOSASZXIRK-UHFFFAOYSA-N |
| SMILES | CCN1CCN(CC1)C2=NC3=CC(Cl)=CC=C3NC4=C(F)C=CC=C24 |
