JHU 37160

For research use only. Not for therapeutic Use.

  • CAT Number: I029782
  • CAS Number: 2369979-68-8
  • Molecular Formula: C19H20ClFN4
  • Molecular Weight: 358.84
  • Purity: 98%
Inquiry Now

JHU 37160(CAT: I029782) is a high-affinity and highly potent activator of the designer receptors exclusively activated by designer drugs (DREADDs) hM3Dq and hM4Di. This compound exhibits approximately 25-fold higher affinity for hM4Di compared to DREADD agonist 21, making it an exceptional tool for chemogenetic studies. By selectively activating these modified muscarinic receptors, JHU 37160 enables precise control over neuronal and cellular signaling pathways, facilitating advanced research in neuroscience, behavioral studies, and therapeutic development. Its superior potency and specificity ensure reliable performance in in vitro and in vivo applications, advancing the understanding of DREADD-mediated mechanisms and translational research.


Catalog Number I029782
CAS Number 2369979-68-8
Synonyms

JHU 37160; JHU37160; JHU-37160;

Molecular Formula C19H20ClFN4
Purity 98%
Target Neuronal Signaling
Solubility Soluble in DMSO
Appearance Solid powder
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name 8-chloro-11-(4-ethylpiperazin-1-yl)-4-fluoro-5H-dibenzo[b,e][1,4]diazepine
InChI InChI=1S/C19H20ClFN4/c1-2-24-8-10-25(11-9-24)19-14-4-3-5-15(21)18(14)22-16-7-6-13(20)12-17(16)23-19/h3-7,12,22H,2,8-11H2,1H3
InChIKey SWSCWOSASZXIRK-UHFFFAOYSA-N
SMILES CCN1CCN(CC1)C2=NC3=CC(Cl)=CC=C3NC4=C(F)C=CC=C24

Request a Quote