For research use only. Not for therapeutic Use.
JI051 is a stabilizer for the Hes1-PHB2 interaction. JI051 interacts with a cancer-associated protein chaperone prohibitin 2 (PHB2), induces cell-cycle arrest by inhibiting the Notch downstream effector gene Hes1. Anti-cancer activity[1].
JI051 causes G2/M cell-cycle arrest[1].
JI051 (0.1-10 µM, 24 hours) significantly inhibits cell proliferation of HEK293 cells, with an EC50 of 0.3 μM[1].
| Catalog Number | I019316 |
| CAS Number | 2234281-75-3 |
| Synonyms | (E)-N-[2-(2-ethoxyphenyl)ethyl]-3-(7-methoxy-1H-indol-3-yl)prop-2-enamide |
| Molecular Formula | C22H24N2O3 |
| Purity | ≥95% |
| InChI | InChI=1S/C22H24N2O3/c1-3-27-19-9-5-4-7-16(19)13-14-23-21(25)12-11-17-15-24-22-18(17)8-6-10-20(22)26-2/h4-12,15,24H,3,13-14H2,1-2H3,(H,23,25)/b12-11+ |
| InChIKey | CQZPBIZGVIRKOC-VAWYXSNFSA-N |
| SMILES | CCOC1=CC=CC=C1CCNC(=O)C=CC2=CNC3=C2C=CC=C3OC |
| Reference | [1]. Perron A, et al. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 May 25;293(21):8285-8294. |
